Glioblastoma Nanomedicine
January 26, 2021 | Terry Sharrer
“Inspired by the capacity of natural proteins and viral particulates to cross the BBB, we [i.e. biointerface scientists at the University of Michigan] engineered a synthetic protein nanoparticle (SPNP) based on polymerized human serum albumin (HSA) equipped with the cell-penetrating peptide iRGD. SPNPs containing siRNA against Signal Transducer and Activation of Transcription 3 factor (STAT3i) result in in vitro and in vivo downregulation of STAT3, a central hub associated with GBM progression. When combined with the standard of care, ionized radiation, STAT3i SPNPs result in tumor regression and long-term survival in 87.5% of GBM-bearing mice and prime the immune system to develop anti-GBM.” MORE
Image Credit: Michigan News