Restoring Hearing Loss from a Genetic Mutation (Mice)
August 4, 2020 | Terry Sharrer
![](http://www.medicalautomation.org/wp-content/uploads/2020/08/Base-editing-for-restoring-hearing-in-mice-Aug-4-300x224.png)
Base editing for restoring hearing in mice
From Harvard researchers: “[We] used base editing methods to treat a mouse model of genetic deafness caused by a point mutation in Tmc1. The authors included a cytosine base editor into a dual–adeno-associated virus (AAV) system and injected it into the inner ear of the animals with hearing loss. The treatment reversed the mutation, improved sensory transduction, and partially restored hearing in mice. These results suggest that base editing might be effective for rescuing recessive genetic hearing loss.” MORE
Image Credit: Susanna M. Hamilton, Broad Communications