Cell by Cell Changes in Xenotransplantation

Cellular dynamics in pig-to-human kidney xenotransplantation
“Early trials of porcine kidney xenotransplantation have been performed on brain-dead human recipients, but the cellular dynamics between xenografts and the recipients’ immune responses remain largely uncharacterized. By employing single-cell and longitudinal RNA sequencing, Pan et al. uncovered the infiltration of human immune cells into the xenografts and the activation of recipients’ immune response, suggesting an early sign of antibody-mediated rejection. Remarkably, the porcine kidney rapidly stimulated cell proliferation, indicating the activation of a tissue repair program post-transplantation. These insights will contribute to the design of new genetically engineered porcine models for optimized xenotransplantation outcomes.” MORE
Image Credit: Cell Press