Re-evaluating Hippo Signaling in Normal Organ Growth
January 24, 2023 | Terry Sharrer
“Mutations that cause dysregulation of the Hippo signaling pathway are known to cause excessive growth of organs, which has led many researchers to think of this pathway as a master regulator of organ growth. Studying fruit fly eye discs and mouse livers, Kowalczyk et al. found instead that Hippo signaling does not instruct normal growth. The Hippo-induced overgrowth phenotypes appear to be caused by Hippo signaling activating abnormal genetic programs. These findings challenge a long-standing idea about the role of Hippo signaling in organ growth and suggest the need to re-evaluate our understanding of its function in other contexts, such as in cancer and regeneration.” MORE
Image Credit: Science.org