Turning Gut Flora against Diabetes
“In this proof-of-concept study, we [gastroenterologists at the University of California, San Diego] use native bacteria as chassis for transgene delivery to impact CR [conventionally raised] host physiology. Native Escherichia coli bacteria isolated from the stool cultures of CR mice were modified to express functional genes. The reintroduction of these strains induces perpetual engraftment in the intestine. In addition, engineered native E. coli can induce functional changes that affect physiology of and reverse pathology in CR hosts months after administration. Thus, using native bacteria as chassis [i.e. support frame] to “knock in” specific functions allows mechanistic studies of specific microbial activities in the microbiome of CR hosts and enables LBT [live bacterial therapeutics] with curative intent.” MORE
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