A Map of the Human Immune Interactome
October 25, 2022 | Terry Sharrer
“Here, using a high-throughput surface receptor screening method, we [at the Wellcome Sanger Institute, Cambridge, UK] systematically mapped the direct protein interactions across a recombinant library that encompasses most of the surface proteins that are detectable on human leukocytes. We independently validated and determined the biophysical parameters of each novel interaction, resulting in a high-confidence and quantitative view of the receptor wiring that connects human immune cells. By integrating our interactome with expression data, we identified trends in the dynamics of immune interactions and constructed a reductionist mathematical model that predicts cellular connectivity from basic principles. MORE
Image Credit: Yurchanka Siarhei/Shutterstock and News Medical Life Sciences