“SuperFi” Gene Editing
June 14, 2022 | Terry Sharrer
“A recent study . . . at The University of Texas at Austin (TX, USA) reveals the redesign of Cas9, a key component of the CRISPR-based gene-editing tool, to make the technology safer. By eliminating the risks involved in CRISPR/Cas9 gene editing and making improvements by recognizing mismatches, the team have provided a proof of concept for the design of next-generation Cas9 variants – without compromising rates of rapid on-target DNA cleavage. . . . . The new SuperFi-Cas9 variant is 4000–times less likely to cut off-target sites on DNA whilst functioning as rapidly as naturally–occurring Cas9 – a factor that has been compromised in previous attempts to create a new Cas9 variant with better discrimination against mismatches.” MORE
Image Credit: Biotechniques.com