Universal Type O Organs for Transplantation
May 3, 2022 | Terry Sharrer
“A major challenge in lung transplantation is the need for ABO blood group matching. To address this challenge, [transplant surgeons, Toronto General Hospital, University Health Network] used two enzymes, FpGalNAc deacetylase and FpGalactosaminidase, to convert blood group A lungs to blood group O lungs during ex vivo lung perfusion. The authors demonstrated successful removal of blood group A antigen with no overt changes in lung health. In an ex vivo simulation of transplantation, the authors showed reduced antibody and complement deposition, suggesting that this technique may reduce antibody-mediated injury in vivo.” MORE
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