Supermeres may care clues to other diseases

“Extracellular vesicles and exomere nanoparticles are under intense investigation as sources of clinically relevant cargo. Here we [cell biologists at Vanderbilt University SOM] report the discovery of a distinct extracellular nanoparticle, termed supermere. Supermeres are morphologically distinct from exomeres and display a markedly greater uptake in vivo compared with small extracellular vesicles and exomeres. The protein and RNA composition of supermeres differs from small extracellular vesicles and exomeres. Supermeres are highly enriched with cargo involved in multiple cancers (glycolytic enzymes, TGFBI, miR-1246, MET, GPC1 and AGO2), Alzheimer’s disease (APP) and cardiovascular disease (ACE2, ACE and PCSK9).”    MORE WITH VIDEO

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