Possible Vaccine for Alzheimer’s
Psychiatric researchers in the UK and Germany “have developed a novel AD vaccine with unique features not related to any other vaccine or antibody in clinical development. The TAPAS family antibodies are uniquely positioned as the antibodies selectively target the early toxic N-terminal truncated species of Aβ found in abundance throughout the brains of AD patients. Moreover, the TAP01 antibody – and its humanised versions – are less likely to become trapped inside plaques thereby increasing the bioavailability after passive immunisation. This decreases the potential for the dose-limiting side effects that have so far proved problematic in clinical trials of other Aβ antibodies. The novel TAPAS family of antibodies have revealed two new attractive options for therapeutic intervention in AD, with either active immunisation using a cyclised peptide based vaccine, or treatment with a humanised TAP01 family therapeutic antibody (passive immunisation).” MORE
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