SEND (Selective Endogenous eNcapsidation for Cellular Delivery)
November 9, 2021 | Terry Sharrer

mRNA gene therapy with a human protein
For a generation, gene therapy has relied on viral vectors to deliver a transgene. But, researchers at MIT’s Broad Institute have found another means of transferring genes which do not, with repeated use, generate an immune response. “PEG10” is a retrovirus-like protein that binds with its own RNA, thus creating a delivery vehicle. “To improve the construct, the researchers added proteins, called “fusogens,” which facilitate the fusion of cells as a critical step for transferring genomic material. These cell surface proteins also allow researchers to direct PEG10 to a particular type of cell, tissue or organ.” MORE
Image Credit: FierceBiotech.com