Human Brain Organoids with Optic Vesicles.
November 2, 2021 | Terry Sharrer
“Using induced pluripotent stem cell (iPSC)-derived human brain organoids, we [researchers at Heinrich-Heine University, Dūsseldorf] attempted to simplify the complexities and demonstrate formation of forebrain-associated bilateral optic vesicles, cellular diversity, and functionality. Around day 30, brain organoids attempt to assemble optic vesicles, which develop progressively as visible structures within 60 days. These optic vesicle-containing brain organoids (OVB-organoids) constitute a developing optic vesicle’s cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progenitor cells, axon-like projections, and electrically active neuronal networks.” MORE
Image Credit: ScienceDirect.com