Engineered Cells Implanted to Reduce Inflammation
November 16, 2021 | Terry Sharrer
Building on their work with anti-inflammatory cartilage cells, researchers at Washington University in St. Louis, have engineered cells that release an immunosuppressant drug when rheumatoid arthritis inflammation flares. “The researchers used CRISPR-Cas9 genome editing technology to make cells that secrete a biologic drug in response to inflammation. The drug reduces inflammation in joints by binding to interleukin-1 (IL-1), a substance that often promotes inflammation in arthritis by activating inflammatory cells in a joint.” This work was done in mice. MORE
Image Credit: NewsHub Washington University in St. Louis,