The Problem of Scar Formation
The Mount Desert Island Biological Laboratory had been deciphering the molecular phenomena of species since 1898, and besides its well-known work mice, its scientists have investigated the regenerative response of the salamander (axolotl). In this piece they “reported that the signaling response of a class of proteins called toll-like receptors (TLRs), which allow macrophages to recognize a threat such an infection or a tissue injury and induce a pro-inflammatory response, were “unexpectedly divergent” in response to injury in the axolotl and the mouse. The finding offers an intriguing window into the mechanisms governing regeneration in the axolotl.” The implication is that this could explain why scaring occurs in the major human organs after injury, and a strategy against scaring could open the process of organ regeneration. MORE
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