Uromodulin Tamm-Horsfall protein

From German medical scientists: “Uromodulin has been associated with arterial hypertension in genome-wide association studies, but data from clinical and preclinical studies are inconsistent. We here analyzed the association of serum uromodulin (sUmod) with arterial hypertension and vasoactive hormones in a population-based study. . . .  We demonstrate an inverse association of sUmod with arterial hypertension and with the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study. Thus, we provide indirect evidence for a systemic blood pressure regulative effect of sUmod. Further studies are required to clarify the mechanistic links between sUmod, arterial hypertension and ET-1.”   MORE WITH VIDEO

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