Creutzfeldt-Jakob disease

While the world has been focused on a virus—SARS-coV-2–prion processes have continued their destruction of tissues quietly.  When did you last hear of a case of Creutzfeldt-Jacob disease?  Its incidence is about 3.5 cases per million people over age of 50.  Still, the fear of a disease arising from misfolded protein is justified, especially if infection can be spread through the food supply.  In this piece, researchers at the University of Massachusetts in Amherst describe how a yeast prion can escape the chaperone system and grow to a size that forms an amyloid plaque in the brain.  MORE

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