“Super Grafts” for Treating Type 1 Diabetes
March 17, 2020 | Terry Sharrer
This piece describes how researchers at the University of Geneva have created transplantable pancreatic grafts for treating Type 1 diabetes. “. . .we show that viable and functional islet organoids can be successfully generated from dissociated islet cells (ICs) and human amniotic epithelial cells (hAECs). Incorporation of hAECs into islet organoids markedly enhances engraftment, viability and graft function in a mouse type 1 diabetes model. . . . Engineering of functional mini-organs using this strategy will allow the exploration of more favorable implantation sites, and can be expanded to unlimited (stem-cell-derived or xenogeneic) sources of insulin-producing cells.” MORE
Image Credit: University of Geneva Medicine