Tailored cell sheet engineering

For surgeries in spatially complex sites such as the middle ear and small intestine, tissue engineers at Yokohama National University have developed “cell sheets” for closing wounds and healing.  “We used microstereolithography, biocompatible gold plating, and electrochemical cell detachment to achieve this purpose. Various objects with dimensions ranging from millimeter- to micrometer-scale were fabricated with photocurable resin using lab-made equipment for microstereolithography. . . .  We further demonstrated that cell sheets grown on gold-coated 3D objects were rapidly detached along with the desorption of electroactive-oligopeptide monolayer and transferred to a surrounding hydrogel. This approach may provide a promising strategy to prepare and directly transplant tailor-made cell sheets with suitable configurations.”    MORE

Image Credit:  nature.com