Liver regeneration

Researchers at King’s College London report: “. . .  the existence of a hepatobiliary hybrid progenitor (HHyP) population in human foetal liver using single-cell RNA sequencing. HHyPs are anatomically restricted to the ductal plate of foetal liver and maintain a transcriptional profile distinct from foetal hepatocytes, mature hepatocytes and mature BECs.”   In short, these hybrid stem cells, in both the fetal and adult liver, mice and humans, have the potential for full liver regeneration.   MORE

Image Credit:  Segal, et al., Nature Communications and Rashid, King’s College London