Moving Closer to Lab-Grown Kidneys
April 30, 2019 | Terry Sharrer
Regenerative medicine researchers at the National Institute for Physiological Sciences (Okazaki, Japan), “show that mouse PSCs [pluripotent stem cells] can efficiently differentiate into the metanephric mesenchyme in rat, allowing the generation of mouse PSC-derived kidney in anephric Sall1 mutant rat. Glomerular epithelium and renal tubules in the kidneys are entirely composed of mouse PSC-derived cells expressing key functional markers. Importantly, the ureter-bladder junction is normally formed. These data provide proof-of-principle for interspecific blastocyst complementation as a viable approach for kidney generation.” MORE
Image Credit: National Institute for Physiological Sciences