Growing Mesenchymal Progenitors without Animal Derived Compounds
Human mesenchymal stem cells are rare and difficult to expand in culture, but they have the greatest capability of rebuilding bone tissue. Researchers at the New York Stem Cell Foundation have found that mesenchymal progenitors, which resemble true stem cells, can be expanded in a culture solution of human platelet lysates and a commercial “Unison Media.” As this report offers, “Human-induced pluripotent stem cell-derived progenitors resemble adult mesenchymal stem cells in morphology, global gene expression, surface antigen profile, and multi-differentiation potential, but unlike adult mesenchymal stem cells, it can be produced in large numbers for every patient. For therapeutic applications, however, human-induced pluripotent stem cell-derived progenitors must be produced without animal-derived components (xeno-free) and in accordance with Good Manufacturing Practice guidelines.” The “xeno-free” issue is now resolved. MORE
Image Credit: NYSCF