Turbulence Propels Stem Cells into Platelets
October 2, 2018 | Terry Sharrer
In this case, the “martini” is both shaken and stirred. Japanese stem cell scientists that “turbulence” in a bioreactor is what prompts thrombopoiesis. “The identification of turbulent energy as a determinant parameter allowed scale-up to 8 L for the generation of 100 billion-order platelets from hiPSC-MKs, which satisfies clinical requirements. Turbulent flow promoted the release from megakaryocytes of IGFBP2, MIF, and Nardilysin to facilitate platelet shedding. hiPSC-platelets showed properties of bona fide human platelets, including circulation and hemostasis capacities upon transfusion in two animal models.” MORE
Image Credit: Kyoto University