Microplates create neural networks

In order to create brain-on-a-chip devices, neuroengineers have to be able to connect neuron to neuron into an engineered network.  In this piece, researchers at the University of Tokyo“describe a method for controlling the axon and dendrite morphology of single primary-cultured neurons and assembling a neural circuit using mobile microplates. The microplates enabled morphological control of neurons by their shapes and bringing their ends into contact caused the formation of physical connections. Functional synapse formation at the connection was indicated by immunostaining of synapse-related proteins and intracellular Ca2+ imaging of neural activity.”  MORE

Image Credit:  University of Tokyo