Gene Therapy Nanoparticles that Enhance CAR-T Therapy
October 17, 2017 | Terry Sharrer
Some of the excitement over chimeric antigen receptor T cell therapy for cancer has diminished following the first patient death. But that was known risk because the engineered T cells can attack healthy as well as disease tissue. To deal with that problem, scientists at the Fred Hutchinson Cancer Center have designed nanoparticle that can deliver new instructions to the target cells. “The nanoparticles home in on specific cells, such as the T cells in the immune system. They then deposit messenger RNA (mRNA) to those cells, which triggers short-term changes in the proteins the genes produce. The technology does not permanently change the DNA, but it makes enough of an impact on it to produce a therapeutic outcome.” MORE
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