New Findings for Bioengineering Livers
August 1, 2017 | Terry Sharrer
The advantages of culturing tissue in three dimensions have been demonstrated since Alexis Carrel pioneered the hanging drop method in 1912, but exactly why that is so has been a mystery that single cell RNA sequencing is now beginning to explain. Researchers at Cincinnati Children’s Hospital have used this sequencing method to understand the complex signaling that takes place between vascular cells, connective tissue and hepatic cells in growing embryonic liver cells into larger organoids. This study focused on the essential signaling between VEGF and VEGFR2 receptor in forming blood vessels in regenerated tissue compared to embryonic and adult liver structures. MORE
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